The solubility properties of organic compounds, which the various organic functional groups impart on organic molecules containing them, is an extremely theme in biochemistry.

For example, a major influence upon the conformation of a globular protein in aqueous solution is the solubility of the amino acid side-chains. In aqueous solution, a protein will assume a low internal energy conformation where the regions with many nonpolar side chains are on the interior of the protein, sequestered from water, and the regions with polar side chains are on the exterior, hydrogen bonding with water.