The Citric Acid Cycle

Alcohols

Carboxylic Acids and Derivatives

Oxidation-Reduction

Oxidation-Reduction in Organic Chemistry

Read for comprehension. Catalyzed by isocitrate dehydrogenase, the oxidation of isocitrate by NAD⁺ converts a hydroxyl group to an aldehyde forming a β-keto acid, a species that is very susceptible to decarboxylization. The decarboxylization of this β-keto acid (oxalosuccinate) forms α-ketoglutarate. Therefore, the conversion of isocitrate to α-ketoglutarate yields NADH and CO₂.