Enzyme catalyzed reactions that are similar to reductive amination are a very important class in biochemistry. If the substrate for substitution of a carbonyl group for an amine is an α-keto acid, such as many important glycolytic or citric acid cycle intermediates (pyruvate, oxaloacetate, etc) the product of the reaction is an α-amino acid (alanine, aspartate, etc.). The conversion of uracil to cytosine (uridine triphosphate to cytidine triphosphate) is an enzyme catalyzed amination. A subclass of amination reactions begins with the conversion of the carbonyl oxygen into a phosphoryl ester, making the oxygen more apt to depart following nucleophilic addition of the amine. This latter class is particularly important in purine biosynthesis.

The WikiPremed MCAT Course is a comprehensive course in the undergraduate level general sciences. Undergraduate level physics, chemistry, organic chemistry and biology are presented by this course as a unified whole within a spiraling curriculum. Please read our policies on Privacy and Shipping & Returns.  Contact Us. MCAT is a registered trademark of the Association of American Medical Colleges, which does not endorse the WikiPremed Course. WikiPremed offers the customers of our publications or our teaching services no guarantees regarding eventual performance on the MCAT.

Creative Commons License
WikiPremed is a trademark of Wisebridge Learning Systems LLC. The work of WikiPremed is published under a Creative Commons Attribution NonCommercial ShareAlike License. There are elements of work here, such as a subset of the images in the archive from WikiPedia, that originated as GNU General Public License works, so take care to follow the unique stipulations of that license in printed reproductions.