The factual basis of the following discussion is a step past the MCAT. The point is to help your general fluency. Read for comprehension. Save memorization for medical school.

Fatty acids are broken down by oxidation at the β-carbon. The process begins on the outer mitochondrial membrane by conversion of the fatty acid and ATP into acyl Coa and AMP by fatty acid synthetase. After a complex transport mechanism into the mitochondrial matrix, the acyl Coa is broken down by a repeating sequence of four reactions : oxidation by FAD (dehydrogenation), hydrolysis, oxidation by NAD+ (conversion of a hydroxyl group into a carbonyl group), then thioloysis at the β-carbon, acyl transfer releasing acetyl CoA and producing a new acyl CoA shortened by two carbon atoms. The pathway from acyl Coa to enol Coa to hydroxyacyl CoA to ketoacyl CoA resembles the pathway in the citric acid cycle of succinate to fumarate to malate to oxaloacetate.

The WikiPremed MCAT Course is a comprehensive course in the undergraduate level general sciences. Undergraduate level physics, chemistry, organic chemistry and biology are presented by this course as a unified whole within a spiraling curriculum. Please read our policies on Privacy and Shipping & Returns.  Contact Us. MCAT is a registered trademark of the Association of American Medical Colleges, which does not endorse the WikiPremed Course. WikiPremed offers the customers of our publications or our teaching services no guarantees regarding eventual performance on the MCAT.

Creative Commons License
WikiPremed is a trademark of Wisebridge Learning Systems LLC. The work of WikiPremed is published under a Creative Commons Attribution NonCommercial ShareAlike License. There are elements of work here, such as a subset of the images in the archive from WikiPedia, that originated as GNU General Public License works, so take care to follow the unique stipulations of that license in printed reproductions.