It was only after quite a bit of reflection that I decided to include significantly challenging biochemistry in these discussions. On the one hand, there is a tendency for premedical students to always feel like they need to memorize everything, so I am concerned about students freaking out, but as I have been trying to get across, the MCAT writers are especially fond of questions involving organic chemistry reactions that play an important role in biochemistry, so biochemistry is an important context for the test as an agency of influence. Furthermore, although the full biochemistry course is not a prerequisite for the MCAT, in my opinion, the biochemistry that does make it onto the exam is a good step beyond the typical treatment of the biochemistry topics in Biology 101. To obtain a truly superior biology score, students should definitely be comfortable reading biochemistry discussion. So those were compelling reasons for me, and I have not even mentioned the importance of biochemistry as profoundly clarifying for the rest of biology.

That being said, let me point out that acyl exchange and nucleophilic addition to aldehydes and ketones occur repeatedly with only a few exceptions over the dozen or so reactions in purine biosynthesis.

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