Integrated SequencePhysics Chemistry Organic Biology

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University of Arizona - Biochemistry 462a Notes - Enzyme Mechanisms
Excellent, in depth notes. Remember full out Biochemistry is not an MCAT prerequisite, but you need to be able to follow discussions at this level.



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Special points of emphasis

Intermolecular Forces

Chemical Kinetics

Reactions of Carboxylic Acids and Derivatives

Coordination Chemistry

Proteins

The Digestive System and Nutrition

Enzymes catalyze reactions by doing one or more of the following: bringing reacting substances into close proximity, binding substrates in precise orientations, polarizing substrates, destabilizing reagents or stabilizing transition states. Enzymes often bring reactants together in the presence of catalytic functional groups within the active site. Substrates are usually bound to enzymes exclusively by noncovalent interactions but sometimes other forms of binding may be involved. For example, the pancreatic enzyme carboxypeptidase A binds its substrate in the active site by intermolecular forces, a coordinate covalent bond, and a salt bridge. With this enzyme, other side chains serve respectively as the nucleophile for hydrolytic acyl exchange and proton donation.







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