Integrated SequencePhysics Chemistry Organic Biology

Web Resources

University of Maryland - Peptide Bond Hydrolysis
Acyl exchange mechanisms are probably the most significant class of reactions in biochemistry, making them a favorite for the MCAT. Dehydration and hydrolysis are acyl exchange mechanisms. The link goes to hydrolysis of a peptide bond A great number of biochemical pathways involve nucleophilic acyl substitution at some stage.



  click if a link is broken



Special points of emphasis

Reactions of Carboxylic Acids and Derivatives

Proteins

Lipids

Bioenergetics and Cellular Respiration

Integration of Metabolism

Acyl exchange mechanisms prominently figure in the anabolic and catabolic processes of biosynthesis of several groups of macromolecules. Formation of the amide linkages in proteins (peptide bonds) occurs through an acyl exchange mechanism, and so does the formation of ester linkages in a triglyceride. Formation of the ester linkages in a triglyceride are acyl exchange mechanisms leading to the loss of the hydroxyl portion of the carboxyl group as water (dehydration). Many of the reactions of the thioester acetyl coA involve nucleophilic acyl substitution.







The WikiPremed MCAT Course is a free comprehensive course in the undergraduate level general sciences. Undergraduate level physics, chemistry, organic chemistry and biology are presented by this course as a unified whole within a spiraling curriculum.

Please read our policies on privacy and shipping & returns.  Contact Us.
MCAT is a registered trademark of the Association of American Medical Colleges, which does not endorse the WikiPremed Course.


Creative Commons License
The work of WikiPremed is published under a Creative Commons Attribution Share Alike 3.0 License. There are elements of work here, such as a subset of the images in the archive from WikiPedia, that originated as GNU General Public License works, so take care to follow the unique stipulations of that license in printed reproductions. You can use the resources here for commercial or non-commercial purposes, but please give attribution and a link to the production credits and edit history of the resource. For the works here which began as my individual work, please attribute "John Wetzel, an author at wikipremed.com".