Integrated SequencePhysics Chemistry Organic Biology

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University of Maryland - Peptide Bond Hydrolysis
Acyl exchange mechanisms are probably the most significant class of reactions in biochemistry, making them a favorite for the MCAT. Dehydration and hydrolysis are acyl exchange mechanisms. The link goes to hydrolysis of a peptide bond A great number of biochemical pathways involve nucleophilic acyl substitution at some stage.

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Special points of emphasis

Reactions of Carboxylic Acids and Derivatives



Bioenergetics and Cellular Respiration

Integration of Metabolism

Acyl exchange mechanisms prominently figure in the anabolic and catabolic processes of biosynthesis of several groups of macromolecules. Formation of the amide linkages in proteins (peptide bonds) occurs through an acyl exchange mechanism, and so does the formation of ester linkages in a triglyceride. Formation of the ester linkages in a triglyceride are acyl exchange mechanisms leading to the loss of the hydroxyl portion of the carboxyl group as water (dehydration). Many of the reactions of the thioester acetyl coA involve nucleophilic acyl substitution.

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