Nucleophiles and Electrophiles
Reactions of Alkyl Halides
Reactions of Alcohols and Ethers
|A halohydrin is a molecule with both a hydroxyl group and a halide substituent. A halohydrin contains both a nucleophile (hydroxyl oxygen) and a leaving group (halide). Under basic conditions, such a molecule will undergo an intramolecular SN2 reaction (similar to Williamson ether synthesis) to form an epoxide.|
Epoxides can also be formed be reaction of alkenes with peroxy acid.
Epoxides seem to be a little bit more important on the MCAT than they are in 1st year organic chemistry. I have had students mention epoxides on previous exams multiple times over the years.