Integrated SequencePhysics Chemistry Organic Biology

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Intramolecular Cationic Rearrangements

Reactions of Aromatic Compounds

Reactions of Aldehydes and Ketones

The electrophile in Friedel-CraftsAlkylation is a carbocation derived from an alkyl halide reagent. The carbocation may be subject to rearrangement. This means that it cannot be used in synthesis to attach a primary alkyl chain more than two carbons long to an aromatic ring. To accomplish that goal, the alternative reaction must be used of Friedel-Crafts acylation, followed by reduction through Clemmensen reduction or Wolff-Kishner reduction. Friedel-Crafts alkylation of a primary alkyl chain would result in rearrangement.

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